| Identification | Back Directory | [Name]
SWE101 | [CAS]
2376322-12-0 | [Synonyms]
SWE101
SWE101,SWE-101
2-Oxazolebutanoic acid, 4-(3,4-dichlorophenyl)-5-phenyl- | [Molecular Formula]
C19H15Cl2NO3 | [MDL Number]
MFCD32201101 | [MOL File]
2376322-12-0.mol | [Molecular Weight]
376.23 |
| Chemical Properties | Back Directory | [Boiling point ]
533.3±50.0 °C(Predicted) | [density ]
1.341±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.62±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SWE101 (compound 22 b) is a potent soluble epoxide hydrolase (sEH)-P inhibitor with IC50s of 4 μM and 2.8 μM for human and rat sEH-P, respectively. SWE101 does not inhibit neither hydrolase nor phosphatase activity of the mouse sEH[1]. | [References]
[1] Kramer JS, et al. Discovery of first in vivo active inhibitors of soluble epoxide hydrolase (sEH) phosphatase domain. J Med Chem. 2019 Aug 22. DOI:10.1021/acs.jmedchem.9b00445 |
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