| Identification | Back Directory | [Name]
5-Benzoxazolecarboxamide, 2-[butyl[(1R)-1-[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]ethyl]amino]-N-methyl- | [CAS]
2378640-10-7 | [Synonyms]
ChemR23-IN-1
5-Benzoxazolecarboxamide, 2-[butyl[(1R)-1-[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]ethyl]amino]-N-methyl- | [Molecular Formula]
C28H29N7O2 | [MOL File]
2378640-10-7.mol | [Molecular Weight]
495.58 |
| Hazard Information | Back Directory | [Uses]
ChemR23-IN-1 (compound 2) is a ChemR23 inhibitor with IC50s of 38 nM and 100 nM for human and mouse ChemR23, respectively. ChemR23-IN-1 inhibits chemotaxis of CAL-1 triggered by Chemerin in vitro[1]. | [References]
[1] Takamichi Imaizumi, et al. The design, synthesis and evaluation of 2-aminobenzoxazole analogues as potent and orally efficacious ChemR23 inhibitors. Bioorg Med Chem. 2020 Sep 1;28(17):115622. DOI:10.1016/j.bmc.2020.115622 |
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