| Identification | Back Directory | [Name]
1,3-Dioxolo[4,5-c]pyridine-6-carboxamide, N-[3-[(2S,5R)-6-amino-5-(ethylsulfonyl)-2-(fluoromethyl)-2,3,4,5-tetrahydro-5-methyl-2-pyridinyl]-4-fluorophenyl]-2,2-difluoro- | [CAS]
2380313-26-6 | [Synonyms]
JNJ-67569762
1,3-Dioxolo[4,5-c]pyridine-6-carboxamide, N-[3-[(2S,5R)-6-amino-5-(ethylsulfonyl)-2-(fluoromethyl)-2,3,4,5-tetrahydro-5-methyl-2-pyridinyl]-4-fluorophenyl]-2,2-difluoro- | [Molecular Formula]
C22H22F4N4O5S | [MOL File]
2380313-26-6.mol | [Molecular Weight]
530.49 |
| Hazard Information | Back Directory | [Uses]
JNJ-67569762 is a selective BACE1 inhibitor targeting the S3 pocket (IC50 = 2.7 nM). | [References]
[1] Rombouts FJR, et al. JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate. J Med Chem. 2021 Oct 14;64(19):14175-14191. DOI:10.1021/acs.jmedchem.1c00935 |
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