| Chemical Properties | Back Directory | [Boiling point ]
850.1±65.0 °C(Predicted) | [density ]
1.162±0.06 g/cm3(Predicted) | [solubility ]
Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
DMSO: Sparingly Soluble: 1-10mg/ml
Methanol: Sparingly Soluble: 1-10mg/ml | [form ]
A solid | [pka]
13.39±0.46(Predicted) | [Sequence]
Phe-{d-Val}-Val-{d-Phe}-NH2 |
| Hazard Information | Back Directory | [Description]
Bilaid A1 is a tetrapeptide agonist of the μ-opioid receptor (Ki = 750 nM in HEK293 cell membranes expressing the human receptor) and a derivative of bilaid A .1 It inhibits forskolin-induced cAMP accumulation by 47% in HEK293 cells expressing the human μ-opioid receptor when used at a concentration of 10 μM. | [Uses]
Bilaid A1e (Compound 1e) is a tetrapeptide agonist of the μ-opioid receptor (Ki = 750 nM). Bilaid A1e can be isolated from an Australian estuarine isolate of Penicillium sp. Bilaid A1e can be used for pain research[1]. | [IC 50]
μ Opioid Receptor/MOR: 750 nM (Ki) | [References]
1. Dekan, Z., Sianati, S., Yousuf, A., et al. A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptor Proc. Natl. Acad. Sci. USA 116(44),22353-22358(2019). |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
ChemeGen
|
| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
| Company Name: |
Fuan Bio
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| Tel: |
15002819872 |
| Website: |
fuanbio.com / www.fuanbio.com |
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