| Identification | Back Directory | [Name]
Benzenesulfonic acid, 4-[(2-chlorobenzoyl)amino]-, 3-nitrophenyl ester | [CAS]
2395016-49-4 | [Synonyms]
P2Y2R/GPR17 antagonist 1
Benzenesulfonic acid, 4-[(2-chlorobenzoyl)amino]-, 3-nitrophenyl ester | [Molecular Formula]
C19H13ClN2O6S | [MOL File]
2395016-49-4.mol | [Molecular Weight]
432.83 |
| Chemical Properties | Back Directory | [Boiling point ]
548.3±50.0 °C(Predicted) | [density ]
1.514±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (288.80 mM; Need ultrasonic) | [form ]
Solid | [pka]
11.68±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist with IC50 values of 3.17 μM and 1.67 μM against P2Y2R and GPR17, respectively. P2Y2R/GPR17 antagonist 1 shows excellent metabolic stability in human liver microsomes[1]. | [storage]
Store at -20°C | [References]
[1] Pillaiyar T, et al. Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17. Eur J Med Chem. 2020 Jan 15;186:111789. DOI:10.1016/j.ejmech.2019.111789 |
|
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|