| Identification | Back Directory | [Name]
7,27-dihydroxycholesterol | [CAS]
240129-43-5 | [Synonyms]
7β
27-DHC
Cholesterol Impurity 36
7,27-dihydroxycholesterol
7ss,27-dihydroxycholesterol
7β,27-dihydroxy Cholesterol
(3β,7β,25R)-Cholest-5-ene-3,7,26-triol
Cholest-5-ene-3,7,26-triol, (3β,7β,25R)-
7β,27dihydroxy Cholesterol,7β,27 dihydroxy Cholesterol | [Molecular Formula]
C27H46O3 | [MDL Number]
MFCD22416720 | [MOL File]
240129-43-5.mol | [Molecular Weight]
418.65 |
| Chemical Properties | Back Directory | [Boiling point ]
552.622±35.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.083±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 2 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2) (1:2): 0.30 mg/ml | [form ]
A crystalline solid | [pka]
14.106±0.70(predicted) | [color ]
White to off-white | [InChIKey]
RXMHNAKZMGJANZ-BMOLSTJGSA-N | [SMILES]
[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=C[C@@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC[C@@H](C)CO |
| Hazard Information | Back Directory | [Uses]
(3β,7β,25R)-Cholest-5-ene-3,7,26-triol is a steroid derivative is used as an important signaling molecule. Oxygenated derivative of cholesterol. | [Definition]
ChEBI: 7beta,27-dihydroxycholesterol is a bile acid. | [Biological Activity]
7β,27-dihydroxycholesterol (7β27OHC) is a retinoid-related orphan receptor γ (RORγ) ligand. 7β27OHC favors smoothened (Smo) functionality. | [in vivo]
7?,27-Dihydroxycholesterol (60 mg/kg; s.c.; twice daily for 3 d) induces IL-17 production in mice in vivo[1]. | [IC 50]
RORγt: 120 nM (Ki) |
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| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|