| Identification | Back Directory | [Name]
7BETA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7 | [CAS]
349553-97-5 | [Synonyms]
5-Cholestene-3,7-diol-d7
7-Hydroxy Cholesterol-d7
Cholest-5-ene-3,7-diol-d7
7β-hydroxy Cholesterol-d7
7-Hydroxycholest-5-en-3-ol-d7
(3,7)-Cholest-5-ene-3,7-diol-d7
7β-Hydroxycholesterol-25,26,26,26-27,27,27-D7
7β-Hydroxycholesterol-25?26?26?26?27?27?27-[d7]
7BETA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7 | [Molecular Formula]
C26H37D7O2 | [MDL Number]
MFCD01317397 | [MOL File]
349553-97-5.mol | [Molecular Weight]
395.67 |
| Chemical Properties | Back Directory | [Melting point ]
174-178?C | [storage temp. ]
-20°C Freezer | [solubility ]
DMF: 2 mg/ml; DMSO: 0.1 mg/ml; Ethanol: 20 mg/ml | [form ]
A solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A labelled metabolite of Cholesterol | [Uses]
Secondary metabolite of Cholesterol. A representative lot was: 84%d7; 14% d6; 1% d5 with no detectable d0. | [Biological Activity]
7β-hydroxycholesterol-d7 (7β-OHC) along with 7-ketocholesterol (7-KC) plays a key role in atherogenesis. It is distributed extensively in the arterial compartment of apo- E knockout mice. 7βOHC induces apoptosis via activation of glycogen synthase kinase-3 (GSK3). It also triggers reactive oxygen species (ROS) resulting in mitochondrial dysfunction. 7βOHC favors demyelination and is a potential oxidized oxysterol in X-linked adrenoleukodystrophy (X-ALD) disorder. | [storage]
Store at -20°C |
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