| Hazard Information | Back Directory | [Description]
FM26 is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. | [Uses]
FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1]. | [References]
[1] Meijer FA, et al.Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists.J Med Chem. 2020 Jan 9;63(1):241-259. DOI:10.1021/acs.jmedchem.9b01372 |
|
|