| Identification | Back Directory | [Name]
BO-264 | [CAS]
2408648-20-2 | [Synonyms]
BO-264
4-Pyrimidinamine, N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)- | [Molecular Formula]
C18H19N5O3 | [MOL File]
2408648-20-2.mol | [Molecular Weight]
353.38 |
| Chemical Properties | Back Directory | [Boiling point ]
627.9±65.0 °C(Predicted) | [density ]
1.306±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (>25 mg/ml) | [form ]
solid | [pka]
6.69±0.10(Predicted) | [color ]
Off-white | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
BO-264 (2408648-20-2) is a potent (IC50 = 188 nM) inhibitor of transforming acidic coiled-coil 3 (TACC3), an important protein involved in microtubule stability and centrosome integrity.1 TACC3 is frequently upregulated in a broad range of cancers. BO-264 displayed significant anticancer activity in greater than 90% of cell lines in the NCI-60 human cancer cell line panel. Active in vivo in mice injected with JIMT-1 and EMT6 breast cancer cells as well as mouse colon cancer xenografts HCT-116 and CT-26. | [References]
[1] nan |
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