| Identification | Back Directory | [Name]
2-Thiophenecarboxamide, 5-(1-cyclopenten-1-yl)-N-[4-[[2-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-5-fluoro-4-pyrimidinyl]amino]-2-methoxyphenyl]-, rel- | [CAS]
2408882-54-0 | [Synonyms]
BCL6-IN-6
2-Thiophenecarboxamide, 5-(1-cyclopenten-1-yl)-N-[4-[[2-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-5-fluoro-4-pyrimidinyl]amino]-2-methoxyphenyl]-, rel- | [Molecular Formula]
C27H31FN6O2S | [MOL File]
2408882-54-0.mol | [Molecular Weight]
522.64 |
| Chemical Properties | Back Directory | [density ]
1.301±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
11.58±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
BCL6-IN-6 is a potent inhibitor of transcriptional repressor B-cell lymphoma 6 (BCL6). BCL6-IN-6 significantly blocks the interaction of BCL6 with its corepressors and reactivates BCL6 target genes in a dose-dependent manner. BCL6-IN-6 has the potential for the research of diffuse large B-cell lymphoma (DLBCL)[1]. | [Biological Activity]
BCL6-IN-6 is a potent inhibitor of transcriptional repressor B-cell lymphoma 6 (BCL6). BCL6-IN-6 significantly blocks the interaction of BCL6 with its corepressors and reactivates BCL6 target genes in a dose-dependent manner. BCL6-IN-6 has the potential for the research of diffuse large B-cell lymphoma (DLBCL)[1]. | [storage]
Store at -20°C | [References]
[1]. Guo W, et al. Synthesis and Biological Evaluation of B-Cell Lymphoma 6 Inhibitors of N-Phenyl-4-pyrimidinamine Derivatives Bearing Potent Activities against Tumor Growth. J Med Chem. 2020;63(2):676-695. |
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