| Identification | Back Directory | [Name]
1H-Imidazole-5-propanal, α-[[[(1S,3S,4aR,8aS)-1-[(butylmethylamino)methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino]-, (αS)- | [CAS]
2409178-86-3 | [Synonyms]
SARS 3CLpro-IN-1
1H-Imidazole-5-propanal, α-[[[(1S,3S,4aR,8aS)-1-[(butylmethylamino)methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino]-, (αS)- | [Molecular Formula]
C22H38N4O2 | [MOL File]
2409178-86-3.mol | [Molecular Weight]
390.57 |
| Hazard Information | Back Directory | [Uses]
SARS 3CLpro-IN-1 (Compound 3b) is a SARS 3CL protease inhibitor with an IC50 value of 95 μM, as a specific stereo isomer
of the octahydroisochromene scaffold, directs the P1 site imidazole[1]. | [References]
[1] Shin-Ichiro Yoshizawa, et al. Evaluation of an octahydroisochromene scaffold used as a novel SARS 3CL protease inhibitor. Bioorg Med Chem. 2020 Feb 15;28(4):115273. DOI:10.1016/j.bmc.2019.115273 |
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