| Chemical Properties | Back Directory | [density ]
1.540±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
12.927±0.29(predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
NP3-562 is a potent, orally active, tricyclic NLRP3 Inhibitor, with an IC50 of 214 nM. NP3-562 (30 mg/kg, p.o.) inhibits IL-1β release in a mouse acute peritonitis model[1]. | [IC 50]
NLRP3: 214 nM (IC50) | [References]
[1] Juraj Velcicky, et al. Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors. J Med Chem. 2024 Jan 4. DOI:10.1021/acs.jmedchem.3c02098 |
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