| Identification | Back Directory | [Name]
2-Buten-1-amine, 3-fluoro-4-(phenylsulfonyl)-, hydrochloride (1:1), (2Z)- | [CAS]
2409964-40-3 | [Synonyms]
2-Buten-1-amine, 3-fluoro-4-(phenylsulfonyl)-, hydrochloride (1:1), (2Z)- | [Molecular Formula]
C10H12FNO2S.ClH | [MOL File]
2409964-40-3.mol | [Molecular Weight]
265.73 |
| Hazard Information | Back Directory | [Uses]
PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor for abolishing lysyl oxidase activity. PXS-4787 hydrochloride inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4), respectively. PXS-4787 hydrochloride reduces deposition and crosslinking of collagen I secreted by human fibroblasts[1]. | [References]
[1] Chaudhari N, et al. Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis. Nat Commun. 2022 Sep 22;13(1):5555. DOI:10.1038/s41467-022-33148-5 |
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