| Identification | Back Directory | [Name]
Sovilnesib | [CAS]
2410796-79-9 | [Synonyms]
AMG-650
Sovilnesib
AMG 650（Sovilnesib）
Sovilnesib (Synonyms: AMG 650)
Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[2-(4,4-difluoro-1-piperidinyl)-6-methyl-4-pyrimidinyl]-4-[[(2-hydroxyethyl)sulfonyl]amino]- | [Molecular Formula]
C26H34F2N6O4S | [MOL File]
2410796-79-9.mol | [Molecular Weight]
564.65 |
| Chemical Properties | Back Directory | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
7.48±0.10(Predicted) | [color ]
White to off-white | [InChIKey]
KBDGEJDIHZDPHN-UHFFFAOYSA-N | [SMILES]
C(NC1C=C(C)N=C(N2CCC(F)(F)CC2)N=1)(=O)C1=CC=C(NS(CCO)(=O)=O)C=C1N1CCC2(CC2)CC1 |
| Hazard Information | Back Directory | [Description]
Sovilnesib (AMG 650) is a kinesin-like protein KIF18A inhibitor (WO2020132648). Sovilnesib can be used for the research of cancer. | [Uses]
Sovilnesib (AMG 650) is a potent, orally active kinesin-like protein KIF18A inhibitor with an IC50 value of 0.071 μM. Sovilnesib can be used for the research of cancer[1][2]. | [in vitro]
Sovilnesib is a kinesin-like protein KIF18A inhibitor. | [in vivo]
Sovilnesib (AMG 650; 10-100 mg/kg; p.o. daily, for 45 d; female nude mice without thymus with OVCAR-3 xenografts) inhibits tumor growth, Lasting tumor regression and cure occurred in 50% of the animals, Sovilnesib has no apparent toxicity.
| [Clinical claims and research]
Sovilnesib (AMG-650) is under development for the treatment of triple-negative breast cancer (TNBC), platinum-resistant high grade serous ovarian cancer, primary peritoneal cancer, fallopian tube cancer, serous endometrial cancer and other solid tumors with TP53 gene mutation (TP53MUT). The drug candidate is administered orally as tablet. It acts by targeting KIF18A.
| [References]
[1] Payton MN, et, al. Kif18a inhibitors for treatment of neoplastic diseases. WO2021211549
[2] Tamayo NA, et, al. Kif18a inhibitors. WO2020132648. |
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| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Wuhan Topule
|
| Telephone: |
+86-02787215551 19945035818 |
| Website: |
http://www.topule.com/ |
|