| Identification | Back Directory | [Name]
1H-Purine-2,6-dione, 8-[(3R)-3-amino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[3-[4-(3-phenyl-1,2,4-oxadiazol-5-yl)-1-piperazinyl]propyl]-, hydrochloride (1:1) | [CAS]
2411099-68-6 | [Synonyms]
1H-Purine-2,6-dione, 8-[(3R)-3-amino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[3-[4-(3-phenyl-1,2,4-oxadiazol-5-yl)-1-piperazinyl]propyl]-, hydrochloride (1:1) | [Molecular Formula]
C30H38N10O3.ClH | [MOL File]
2411099-68-6.mol | [Molecular Weight]
623.15 |
| Hazard Information | Back Directory | [Uses]
DPP-4/GPR119 modulator 1 (Compound 22) is an orally active dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist. DPP-4/GPR119 modulator 1 shows blood glucose-lowering effect and moderate inhibition on hERG channel with an IC50 of 4.9 μM. DPP-4/GPR119 modulator 1 can be used for diabetes research[1][1]. DPP-4/GPR119 modulator 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
DPP-4 | [References]
[1] Li G, et al. The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119. Eur J Med Chem. 2020 Feb 15;188:112017. DOI:10.1016/j.ejmech.2019.112017 |
|
|