| Identification | Back Directory | [Name]
yGsy2p-IN-1 | [CAS]
2415003-97-1 | [Synonyms]
yGsy2p-IN-1
1,2,3-Benzenetriol, 4-[4-(4-hydroxyphenyl)-5-(trifluoromethyl)-1H-pyrazol-3-yl]-
diseases,synthase,hGYS1,pyrazole,GSDs,yGsy2p,yGsy2pIN1,yGsy-2p-IN-1,glycogen,storage,yGsy2p IN 1,Inhibitor,inhibit,human,yeast | [Molecular Formula]
C16H11F3N2O4 | [MOL File]
2415003-97-1.mol | [Molecular Weight]
352.26 |
| Chemical Properties | Back Directory | [Boiling point ]
561.0±50.0 °C(Predicted) | [density ]
1.610±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
8.03±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC50 of 2.75 μM and a Ki of 1.31 μM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs)[1]. | [References]
[1] Buyun Tang, et al. Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. J Med Chem. 2020 Apr 9;63(7):3538-3551. DOI:10.1021/acs.jmedchem.9b01851 |
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