| Identification | Back Directory | [Name]
3(2H)-Benzoxazolecarboxamide, 6-(1-methyl-4-piperidinyl)-N-(2-methylpropyl)-2-oxo- | [CAS]
2415225-30-6 | [Synonyms]
Acid Ceramidase-IN-1
3(2H)-Benzoxazolecarboxamide, 6-(1-methyl-4-piperidinyl)-N-(2-methylpropyl)-2-oxo- | [Molecular Formula]
C18H25N3O3 | [MOL File]
2415225-30-6.mol | [Molecular Weight]
331.41 |
| Hazard Information | Back Directory | [Uses]
Acid Ceramidase-IN-1 is a potent and oral bioavailable acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 μM). Acid Ceramidase-IN-1 has excellent brain penetration in mice[1]. | [Biological Activity]
Acid Ceramidase-IN-1 is a potent and oral bioavailable acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 μM). Acid Ceramidase-IN-1 has excellent brain penetration in mice[1]. | [References]
[1]. Di Martino S, et al. Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors. J Med Chem. 2020;63(7):3634-3664. |
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