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2415653-55-1

2415653-55-1 Structure

2415653-55-1 Structure
IdentificationBack Directory
[Name]

Urea, N-(3,5-dichlorophenyl)-N′-(6-nitro-2-benzothiazolyl)-
[CAS]

2415653-55-1
[Synonyms]

Urea, N-(3,5-dichlorophenyl)-N′-(6-nitro-2-benzothiazolyl)-
[Molecular Formula]

C14H8Cl2N4O3S
[MOL File]

2415653-55-1.mol
[Molecular Weight]

383.21
Chemical PropertiesBack Directory
[density ]

1.722±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[form ]

Solid
[pka]

6.80±0.70(predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

CXCL-CXCR1/2-IN-1 is an orally active ELR+CXCL-CXCR1/2 pathway inhibitor with an EC50 of 42.7 nM for CXCR2[1]. CXCL-CXCR1/2-IN-1 shows anticancer and antiangiogenic effects[1].
[in vivo]

CXCL-CXCR1/2-IN-1 (1 μM; 48 h) reduces metastasis area in zebrafish embryos injected with A498 cells[1].
CXCL-CXCR1/2-IN-1 (100 mg/kg; oral gavage; twice a day; for 28 days) inhibits tumor growth in mice[1].

Animal Model:Female NOD SCID mice injected with 786 RCC cells[1]
Dosage:100 mg/kg
Administration:Oral gavage; twice a day; for 28 days
Result:Exhibited remarkable results, with a tumor growth inhibition rate of 87%.
[References]

[1] Oleksandr Grytsai, et al. A Potent Solution for Tumor Growth and Angiogenesis Suppression via an ELR+CXCL-CXCR1/2 Pathway Inhibitor. ACS Med. Chem. Lett. April 3, 2024.
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