| Identification | Back Directory | [Name]
2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)- | [CAS]
2415941-98-7 | [Synonyms]
FAP-PI3KI1
2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)- | [Molecular Formula]
C52H48F4N10O12S3 | [MOL File]
2415941-98-7.mol | [Molecular Weight]
1177.19 |
| Hazard Information | Back Directory | [Uses]
FAP-PI3KI1 is a fibroblast-activated protein (FAP)-targeted PI3K inhibitor that selectively targets FAP-expressing human idiopathic pulmonary fibrosis (IPF) cells and effectively inhibits collagen synthesis and reduces collagen deposition[1]. | [References]
[1] Suraj U Hettiarachchi, et al. Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models. Sci Transl Med. 2020 Oct 28;12(567):eaay3724. DOI:10.1126/scitranslmed.aay3724 |
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| Company Name: |
Fuan Bio
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| Telephone: |
15002819872 |
| Website: |
fuanbio.com |
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