| Identification | More | [Name]
4-Hydroxyphenyl hydantoin | [CAS]
2420-17-9 | [Synonyms]
4-HYDROXYPHENYL HYDANTOIN
5-(4-HYDROXYPHENYL)2,4-IMIDAZOLIDINEDIONE
5-(4-HYDROXYPHENYL)HYDANTOIN
5-(P-HYDROXYPHENYL)HYDANTOIN
RARECHEM AP KH 0026
5-(4-Hydroxyphenyl)2,4-Imidazolidinedine
Hydroxyphenylhydantoin
5-(4-hydroxyphenyl)imidazolidine-2,4-dione
5-(4-Hydroxy Phenyl) Hydantion
4-Hydroxyphenyhydantoin
5-(4-Hydroxylphenyl)hydantoin
p-Hydroxyphenylhydantoin
5-(4-HYDROXYPHENYL)HYDANTOIN 98+% | [EINECS(EC#)]
219-340-8 | [Molecular Formula]
C9H8N2O3 | [MDL Number]
MFCD00044002 | [Molecular Weight]
192.17 | [MOL File]
2420-17-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
>260°C | [Boiling point ]
273.7℃[at 101 325 Pa] | [density ]
1.408 | [vapor pressure ]
0Pa at 25℃ | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
powder to crystal | [pka]
8.67±0.10(Predicted) | [color ]
White to Almost white | [Water Solubility ]
1.29g/L at 20℃ | [InChI]
InChI=1S/C9H8N2O3/c12-6-3-1-5(2-4-6)7-8(13)11-9(14)10-7/h1-4,7,12H,(H2,10,11,13,14) | [InChIKey]
UMTNMIARZPDSDI-UHFFFAOYSA-N | [SMILES]
C1(=O)NC(C2=CC=C(O)C=C2)C(=O)N1 | [LogP]
-0.03 at 20℃ | [CAS DataBase Reference]
2420-17-9(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
5-(4-Hydroxyphenyl)-2,4-imidazolidinedione is used in the synthesis of D-p-hydroxyphenylglycine, it is an important pharmaceutical intermediate in the production of amoxicillin, cephalosporins, etc. As a side chain of β-lactam semi-synthetic antibiotics, it is used in the production of antibiotics such as amoxicillin, which have broad-spectrum antibacterial properties and are convenient to use. | [Flammability and Explosibility]
Nonflammable | [Synthesis]
Add 4.0 g of glyoxylic acid monohydrate (0.04 mol), 1.2 g of urea (0.02 mol), and 10 mL of 10% hydrochloric acid into the beaker. Stir evenly. After releasing the heat, pour it into a dropping funnel and set aside. Add 3.6 g (0.06 mol) of urea, 5.6 g (0.06 mol) of phenol, and 10% hydrochloric acid, and stir evenly in a three-necked flask. Heat to 90 ℃, slowly add the glyoxylic acid-urea mixture dropwise and control the dropping speed for about 4 hours. After the dropwise addition is completed, continue the heat preservation reaction for 2 hours to complete the reaction. Change the reaction device to a vacuum distillation device to recover excess phenol. After evaporating about 1/3 of the volume of the solution, cool to about 15°C to crystallize, filter, and use the filter cake. Wash with water 2 to 3 times until neutral and dry to obtain 5.8 g of white solid 5-(4-Hydroxyphenyl)-2,4-imidazolidinedione.
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
T&W GROUP
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| Telephone: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
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