| Identification | Back Directory | [Name]
Pyrazolo[1,5-c]quinazoline-1-carboxylic acid, 8-[(3S)-3-(aminomethyl)-1-pyrrolidinyl]-6-ethyl-9-fluoro-5,6-dihydro-5-oxo-, ethyl ester | [CAS]
2428407-03-6 | [Synonyms]
UIAA-II-232
Pyrazolo[1,5-c]quinazoline-1-carboxylic acid, 8-[(3S)-3-(aminomethyl)-1-pyrrolidinyl]-6-ethyl-9-fluoro-5,6-dihydro-5-oxo-, ethyl ester | [Molecular Formula]
C20H24FN5O3 | [MOL File]
2428407-03-6.mol | [Molecular Weight]
401.43 |
| Hazard Information | Back Directory | [Uses]
UIAA-II-232 (compound 19b) is a potent DNA gyrase catalytic inhibitor with an IC50 value of 3.5 μM[1]. | [References]
[1] Aguirre AL, et al. Identification of an ethyl 5,6-dihydropyrazolo[1,5-c]quinazoline-1-carboxylate as a catalytic inhibitor of DNA gyrase. Bioorg Med Chem. 2020 May 15;28(10):115439. DOI:10.1016/j.bmc.2020.115439 |
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