| Identification | Back Directory | [Name]
4-Fluorobenzylboronic acid pinacol ester | [CAS]
243145-83-7 | [Synonyms]
243145-83-7
2-(4-Fluorobenzyl)
4-Fluorobenzylboronic acid pinacol este
4-fluorobenzylboronic acid pinacol ester
4-Fluorobenzylboronic acid, pinacol ester 95+%
2-(4-Fluorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
4-Fluorobenzylboronic acid pinacol ester ISO 9001：2015 REACH
2-[(4-fluorophenyl)methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
1,3,2-dioxaborolane, 2-[(4-fluorophenyl)methyl]-4,4,5,5-tetramethyl- | [Molecular Formula]
C13H20BFO3 | [MDL Number]
MFCD10698519 | [MOL File]
243145-83-7.mol | [Molecular Weight]
236.09 |
| Chemical Properties | Back Directory | [Boiling point ]
275 °C | [density ]
1.04 | [Fp ]
120 °C | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [form ]
liquid | [color ]
Colourless |
| Questions And Answer | Back Directory | [Application]
In scientific research, boron esters are primarily used as synthetic intermediates in transition metal-catalyzed cross-coupling reactions to construct structurally complex target compounds. In industrial production, boron esters have found wide applications in pharmaceuticals, pesticides, and materials. |
| Hazard Information | Back Directory | [Synthesis]
Example 6: Under argon protection, magnesium shavings (16.8 mg, 0.7 mmol) were added to tetrahydrofuran (1 ml), followed by bis(pinacolato)borate (127.0 mg, 0.5 mmol) and p-fluorobenzyl chloride (162 μl, 1.35 mmol). Fe(acac)3 catalyst (3.5 mg, 0.010 mmol, 2 mol%) was added at 0 °C and the reaction was carried out for 3 hours. Upon completion of the reaction, the reaction was quenched with water and the reaction product was extracted with ethyl acetate. The yield of 4-fluorobenzylboronic acid pinacol ester was calculated to be 93% by gas chromatographic analysis. | [References]
[1] Patent: CN107903281, 2018, A. Location in patent: Paragraph 0028
[2] Green Chemistry, 2012, vol. 14, # 3, p. 661 - 667
[3] Journal of the American Chemical Society, 2014, vol. 136, # 27, p. 9521 - 9523 |
|
|