| Identification | Back Directory | [Name]
Propanamide, 3-[[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-quinazolinyl]amino]-N-methyl-N-2-propyn-1-yl- | [CAS]
2436544-27-1 | [Synonyms]
ARS1323 Alkyne
Propanamide, 3-[[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-quinazolinyl]amino]-N-methyl-N-2-propyn-1-yl- | [Molecular Formula]
C28H27ClF2N6O3 | [MDL Number]
MFCD32067946 | [MOL File]
2436544-27-1.mol | [Molecular Weight]
569 |
| Chemical Properties | Back Directory | [Boiling point ]
767.3±70.0 °C(Predicted) | [density ]
1.398±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, stored under nitrogen | [solubility ]
DMSO : 35.71 mg/mL (62.76 mM; Need ultrasonic) | [form ]
Solid | [pka]
6.00±0.35(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Uses]
ARS-1323-alkyne, a switch-II pocket (S-IIP) inhibitor, is a conformational specific chemical reporter of KRASG12C nucleotide state in living cells[1]. ARS-1323-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
KRAS(G12C) | [storage]
4°C, stored under nitrogen | [References]
[1] Lou K,et al. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 May 28;12(583). pii: eaaw9450. DOI:10.1126/scisignal.aaw9450 |
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