| Identification | Back Directory | [Name]
Benzonitrile, 4-[2-(4-methylphenyl)-5-[(3R)-3-pyrrolidinylmethoxy]-3-pyridinyl]-, hydrochloride (1:1) | [CAS]
2436760-79-9 | [Synonyms]
Benzonitrile, 4-[2-(4-methylphenyl)-5-[(3R)-3-pyrrolidinylmethoxy]-3-pyridinyl]-, hydrochloride (1:1) | [Molecular Formula]
C24H23N3O.ClH | [MOL File]
2436760-79-9.mol | [Molecular Weight]
405.92 |
| Hazard Information | Back Directory | [Uses]
GSK 690 (Hydrochloride) is a reversible inhibitor of lysine specific demethylase 1 (LSD1), with a Kd value of 9 nM and a biochemical IC50 of 37 nM. | [IC 50]
KDM1/LSD1 | [References]
[1] Mould DP, et al. Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1. J Med Chem. 2017 Oct 12;60(19):7984-7999. DOI:10.1021/acs.jmedchem.7b00462
[2] Haydn T, et al. Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells. Cell Death Dis. 2017 Jun 15;8(6):e2879. DOI:10.1038/cddis.2017.239 |
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