| Chemical Properties | Back Directory | [Boiling point ]
1300.977±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.194±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
13.289±0.70(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(Aminooxy)acetamide-Val-Cit-PAB-MMAE (MMAE 5) is an intermediate used in the synthetic preparation of drug-linker conjugates for ADC. (Aminooxy)acetamide-Val-Cit-PAB-MMAE is conjugated to polyamide via oxime bond formation to form MMAE polyamide conjugate. Then MMAE polyamide conjugate can be conjugated to Trastuzumab, to make ADC[1]. | [References]
[1] Ouberai Myriam, et al. Preparation of antibody-drug conjugates using polymers and crosslinkers. World Intellectual Property Organization, WO2020128488 A1. 2020-06-25. |
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