| Identification | Back Directory | [Name]
2H-Furo[2,3-h]-1-benzopyran-2-one, 8-(3,5-dimethoxyphenyl)-4-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]- | [CAS]
2447589-08-2 | [Synonyms]
COX-2-IN-22
2H-Furo[2,3-h]-1-benzopyran-2-one, 8-(3,5-dimethoxyphenyl)-4-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]- | [Molecular Formula]
C29H24O7 | [MOL File]
2447589-08-2.mol | [Molecular Weight]
484.5 |
| Hazard Information | Back Directory | [Uses]
COX-2-IN-22 (Compound 4h) is a COX-2 inhibitor with an IC50 of 8.6 μM. COX-2-IN-22 also inhibits AChE, BChE, β-Secretase, LOX-5 and DPPH with IC50 values of 2.8, 6.3, 15.3, 13.9 and 6.8 μM, respectively. COX-2-IN-22 can cross BBB[1]. | [IC 50]
AChE: 2.8 μM (IC50); BChE: 6.3 μM (IC50); DPPH: 6.8 μM (IC50); COX-2: 8.6 μM (IC50); LOX-5: 13.9 μM (IC50); β-Secretase: 15.3 μM (IC50) | [References]
[1] Agbo EN, et al. Synthesis of furocoumarin-stilbene hybrids as potential multifunctional drugs against multiple biochemical targets associated with Alzheimer's disease. Bioorg Chem. 2020 Aug;101:103997. DOI:10.1016/j.bioorg.2020.103997 |
|
|