| Identification | Back Directory | [Name]
Benzamide, N-[3-(1H-benzimidazol-2-yl)-1H-pyrazol-5-yl]-4-(4-methyl-1-piperazinyl)- | [CAS]
2451093-95-9 | [Synonyms]
Benzamide, N-[3-(1H-benzimidazol-2-yl)-1H-pyrazol-5-yl]-4-(4-methyl-1-piperazinyl)-
N-(3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazol-5-yl)-4-(4-methylpiperazin-1-yl)benzamide | [Molecular Formula]
C22H23N7O | [MOL File]
2451093-95-9.mol | [Molecular Weight]
401.46 |
| Hazard Information | Back Directory | [Uses]
FOXO1-IN-3 is a highly-selective and orally active FOXO1 inhibitor. FOXO1-IN-3 reduces hepatic glucose production in mice. FOXO1-IN-3 improves insulin sensitivity and glucose control in db/db mice without causing weight gain[1]. | [References]
[1] Lee YK, et al. FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice. Mol Metab. 2021 Jul;49:101187. DOI:10.1016/j.molmet.2021.101187 |
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