ChemicalBook--->CAS DataBase List--->2454113-83-6

2454113-83-6

2454113-83-6 Structure

2454113-83-6 Structure
IdentificationBack Directory
[Name]

3-Thiazolidineacetamide, N-2-benzothiazolyl-5-(2-furanylmethylene)-2,4-dioxo-
[CAS]

2454113-83-6
[Synonyms]

GLUT4-IN-2
3-Thiazolidineacetamide, N-2-benzothiazolyl-5-(2-furanylmethylene)-2,4-dioxo-
[Molecular Formula]

C17H11N3O4S2
[MOL File]

2454113-83-6.mol
[Molecular Weight]

385.42
Chemical PropertiesBack Directory
[density ]

1.618±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

8.61±0.70(Predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

GLUT4-IN-2 is a potent and selective GLUT4 inhibitor with IC50s of 11.4 μM and 6.8 μM for GLUT1 and GLUT4, respectively. GLUT4-IN-2 induces cell apoptosis and cell cycle arrest at G0/G1phase. GLUT4-IN-2 shows potent antitumor activity[1].
[in vivo]

GLUT4-IN-2 (50 mg/kg; i.p. on day 1–5, 8–12, 15–18) shows antitumor activity in CEM xenograft model[1].

Animal Model:8–10 weeks, SCID mice (CEM xenograft tumor) [1]
Dosage:50 mg/kg
Administration:I.p.; administered on day 1-5, 8-12, 15-18
Result:Showed potent antitumor activity in vivo.
[IC 50]

GLUT1: 11.4 μM (IC50); GLUT4: 6.8 μM (IC50)
[References]

[1] Tilekar K,et al. Structure guided design and synthesis of furyl thiazolidinedione derivatives as inhibitors of GLUT 1 and GLUT 4, and evaluation of their anti-leukemic potential. Eur J Med Chem. 2020 Sep 15;202:112603. DOI:10.1016/j.ejmech.2020.112603
2454113-83-6 suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 021-13816613772 13816613772
Website: https://www.chemicalbook.com/ShowSupplierProductsList16976/0.htm
Company Name: Guangzhou Younan Technology Co., Ltd  
Tel: 020-82000279 18988968278
Website: http://www.ubiochem.cn/
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Tags:2454113-83-6 Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.