Identification | Back Directory | [Name]
3-Thiazolidineacetamide, N-2-benzothiazolyl-5-(2-furanylmethylene)-2,4-dioxo- | [CAS]
2454113-83-6 | [Synonyms]
GLUT4-IN-2 3-Thiazolidineacetamide, N-2-benzothiazolyl-5-(2-furanylmethylene)-2,4-dioxo- | [Molecular Formula]
C17H11N3O4S2 | [MOL File]
2454113-83-6.mol | [Molecular Weight]
385.42 |
Hazard Information | Back Directory | [Uses]
GLUT4-IN-2 is a potent and selective GLUT4 inhibitor with IC50s of 11.4 μM and 6.8 μM for GLUT1 and GLUT4, respectively. GLUT4-IN-2 induces cell apoptosis and cell cycle arrest at G0/G1phase. GLUT4-IN-2 shows potent antitumor activity[1]. | [in vivo]
GLUT4-IN-2 (50 mg/kg; i.p. on day 1–5, 8–12, 15–18) shows antitumor activity in CEM xenograft model[1]. Animal Model: | 8–10 weeks, SCID mice (CEM xenograft tumor) [1] | Dosage: | 50 mg/kg | Administration: | I.p.; administered on day 1-5, 8-12, 15-18 | Result: | Showed potent antitumor activity in vivo. |
| [IC 50]
GLUT1: 11.4 μM (IC50); GLUT4: 6.8 μM (IC50) | [References]
[1] Tilekar K,et al. Structure guided design and synthesis of furyl thiazolidinedione derivatives as inhibitors of GLUT 1 and GLUT 4, and evaluation of their anti-leukemic potential. Eur J Med Chem. 2020 Sep 15;202:112603. DOI:10.1016/j.ejmech.2020.112603 |
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