| Identification | Back Directory | [Name]
2,4,6,8,20-Pentaazatricyclo[13.3.1.13,7]eicosa-1(19),3,5,7(20),15,17-hexaene, 17-(trifluoromethyl)-5-[6-(trifluoromethyl)-2-pyridinyl]- | [CAS]
2469044-23-1 | [Synonyms]
IDH2R140Q-IN-1
2,4,6,8,20-Pentaazatricyclo[13.3.1.13,7]eicosa-1(19),3,5,7(20),15,17-hexaene, 17-(trifluoromethyl)-5-[6-(trifluoromethyl)-2-pyridinyl]- | [Molecular Formula]
C22H20F6N6 | [MOL File]
2469044-23-1.mol | [Molecular Weight]
482.42 |
| Hazard Information | Back Directory | [Uses]
IDH2R140Q-IN-1 (compound C6) is a potent inhibitor of IDH2R140Q, with an IC50 of 6.1 nM. IDH2R140Q-IN-1 can be used for the research of acute myeloid leukemia[1]. | [References]
[1] Che J, et, al. Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells. Eur J Med Chem. 2020 Oct 1;203:112491. DOI:10.1016/j.ejmech.2020.112491 |
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