| Identification | Back Directory | [Name]
Methanone, (6-fluoro-1H-benzimidazol-2-yl)(7-fluoro-1H-indol-3-yl)- | [CAS]
2476490-18-1 | [Synonyms]
PCSK9 modulator-3
Methanone, (6-fluoro-1H-benzimidazol-2-yl)(7-fluoro-1H-indol-3-yl)- | [Molecular Formula]
C16H9F2N3O | [MOL File]
2476490-18-1.mol | [Molecular Weight]
297.26 |
| Hazard Information | Back Directory | [Uses]
PCSK9 modulator-3 (Compound 13) is a potent modulator of PCSK9 with an EC50 value of 2.46 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C). PCSK9 modulator-3 has the potential for the research of hyperlipidemia[1]. | [References]
[1] Xie H, et al. From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators. Eur J Med Chem. 2020 Nov 15;206:112678. DOI:10.1016/j.ejmech.2020.112678 |
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