| Identification | Back Directory | [Name]
Methanone, (7-fluoro-1H-indol-3-yl)(6-fluoro-1-methyl-1H-benzimidazol-2-yl)- | [CAS]
2476490-20-5 | [Synonyms]
PCSK9 modulator-4
Methanone, (7-fluoro-1H-indol-3-yl)(6-fluoro-1-methyl-1H-benzimidazol-2-yl)- | [Molecular Formula]
C17H11F2N3O | [MOL File]
2476490-20-5.mol | [Molecular Weight]
311.29 |
| Hazard Information | Back Directory | [Uses]
PCSK9 modulator-4 (Compound 21) is a potent modulator of PCSK9 with an EC50 value of 0.15 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C). PCSK9 modulator-4 has the potential for the research of hyperlipidemia[1]. | [References]
[1] Xie H, et al. From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators. Eur J Med Chem. 2020 Nov 15;206:112678. DOI:10.1016/j.ejmech.2020.112678 |
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