| Identification | Back Directory | [Name]
4-Morpholineacetamide, N-[4-(4-chlorophenyl)-3-cyano-2-thienyl]- | [CAS]
2481484-51-7 | [Synonyms]
COX-2/5-LOX-IN-3
4-Morpholineacetamide, N-[4-(4-chlorophenyl)-3-cyano-2-thienyl]- | [Molecular Formula]
C17H16ClN3O2S | [MOL File]
2481484-51-7.mol | [Molecular Weight]
361.85 |
| Hazard Information | Back Directory | [Uses]
COX-2/5-LOX-IN-3 (compound 5b) is a potent and dual COX-2/5-LOX inhibitor with IC50 values of 45.73, 5.45 and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. COX-2/5-LOX-IN-3 has the potential for the research of inflammation diseases[1]. | [in vivo]
COX-2/5-LOX-IN-3 (compound 5b) (p.o.; male Sprague Dawley rats) shows anti-inflammatory activities in vivo[1]. | Animal Model: | Male Sprague Dawley rats[1] | | Dosage: | 2.622 X 10-5 mol/kg | | Administration: | Oral administration | | Result: | The percentage inhibition of edema (%I) reached 58.77% after 4h. |
| [IC 50]
5-LOX: 4.33 μM (IC50); COX-2: 5.45 μM (IC50); COX-1: 45.73 μM (IC50) | [References]
[1] Qandeel NA, et al. Synthesis, in vivo anti-inflammatory, COX-1/COX-2 and 5-LOX inhibitory activities of new 2,3,4-trisubstituted thiophene derivatives. Bioorg Chem. 2020 Sep;102:103890. DOI:10.1016/j.bioorg.2020.103890 |
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