| Identification | Back Directory | [Name]
7H-Pyrrolo[2,3-d]pyrimidine-2,4-diamine, N4-(cis-4-aminocyclohexyl)-N2-(3-chlorophenyl)- | [CAS]
2488706-33-6 | [Synonyms]
PAK4-IN-2
7H-Pyrrolo[2,3-d]pyrimidine-2,4-diamine, N4-(cis-4-aminocyclohexyl)-N2-(3-chlorophenyl)- | [Molecular Formula]
C18H21ClN6 | [MOL File]
2488706-33-6.mol | [Molecular Weight]
356.85 |
| Hazard Information | Back Directory | [Uses]
PAK4-IN-2 is a highly potent PAK4 inhibitor with IC50 value of 2.7 nM. PAK4-IN-2 can arrest MV4-11 cells at G0/G1 phase and induce cell apoptosis. PAK4-IN-2 can be used for researching cancer[1]. | [IC 50]
PAK3: 2.7 nM (IC50) | [References]
[1] Wang C, Xia J, Lei Y, et al. Synthesis and biological evaluation of 7H-pyrrolo [2,3-d] pyrimidine derivatives as potential p21-activated kinase 4 (PAK4) inhibitors. Bioorg Med Chem. 2022;60:116700. DOI:10.1016/j.bmc.2022.116700 |
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