| Identification | Back Directory | [Name]
Azido-PEG10-COOtBu | [CAS]
2490419-48-0 | [Synonyms]
Azido-PEG10-Boc
N3-PEG10-COOtBu
Azido-PEG10-COOtBu
Azido-PEG10-CH2COOtBu | [Molecular Formula]
C27H53N3O12 | [MOL File]
2490419-48-0.mol | [Molecular Weight]
611.73 |
| Hazard Information | Back Directory | [Uses]
Azido-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG10-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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