| Identification | Back Directory | [Name]
Hydrazinecarbothioamide, 2-(1-ethyl-5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-N-[4-(trifluoromethyl)phenyl]- | [CAS]
2490468-31-8 | [Synonyms]
HSV-1/HSV-2-IN-1
Hydrazinecarbothioamide, 2-(1-ethyl-5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-N-[4-(trifluoromethyl)phenyl]- | [Molecular Formula]
C18H14F4N4OS | [MOL File]
2490468-31-8.mol | [Molecular Weight]
410.39 |
| Hazard Information | Back Directory | [Uses]
HSV-1/HSV-2-IN-1 (compound 7d) is a HSV-1 and HSV-2 inhibitor, with EC50s of 7.6, 7.6, 4, and 12 μM for HSV-1 (KOS), HSV-2 (G), HSV-1 TK- KOS ACVr and vaccinia virus in human embryonic lung fibroblast cell cultures[1]. | [IC 50]
HSV-1; HSV-2 | [References]
[1] Sevin?li ZS, et, al. Synthesis, molecular modeling and antiviral activity of novel 5-fluoro-1H-indole-2,3-dione 3-thiosemicarbazones. Bioorg Chem. 2020 Nov;104:104202. DOI:10.1016/j.bioorg.2020.104202 |
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