| Chemical Properties | Back Directory | [Melting point ]
244-246 °C | [Boiling point ]
770.940±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.469±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
14.445±0.46(predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 4.45 and 3.18 μM, respectively[1]. | [IC 50]
Mcl-1: 4.45 μM (IC50); Bcl-2: 3.18 μM (IC50) | [References]
[1] Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163. DOI:10.1021/acs.jmedchem.9b00919 |
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