| Identification | More | [Name]
Pinacolborane | [CAS]
25015-63-8 | [Synonyms]
4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE
PINACOLBORANE
Pinacolboronane
4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE, 1M SOLUTION IN TETRAHYDROFURAN
1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-
4,4,5,5-tetramethyl-1,3,2-dioxaborolane solution
Pinacolborane (PINB)
4,4,5,5-TETRAMETHYL-1,3,2-DIOXA-&
4,4,5,5-Tetramethyl-1,3-dioxa-2$l^{2}-boracyclopentane
4,4,5,5-Tetramethyl-1,3,2-dioxaborole
4,4,5,5-Tetramethyl-1,3-dioxa-2-boracyclopentane | [EINECS(EC#)]
607-485-3 | [Molecular Formula]
C6H17BO2 | [MDL Number]
MFCD00674030 | [Molecular Weight]
132.01 | [MOL File]
25015-63-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear colorless liquid | [Boiling point ]
42-43 °C50 mm Hg(lit.)
| [density ]
0.882 g/mL at 25 °C(lit.)
| [vapor pressure ]
29-119.9hPa at 20-50℃ | [refractive index ]
n20/D 1.396(lit.)
| [Fp ]
41 °F
| [storage temp. ]
Keep Cold | [solubility ]
Miscible with ether, dichloromethane, tetrahydrofuran and organic solvents. | [form ]
Liquid | [color ]
Clear colorless to light yellow | [Specific Gravity]
0.882 | [Sensitive ]
Air Sensitive | [BRN ]
7802871 | [Stability:]
Air Sensitive, Hygroscopic, Moisture Sensitive | [InChI]
InChI=1S/C6H13BO2/c1-5(2)6(3,4)9-7-8-5/h7H,1-4H3 | [InChIKey]
UCFSYHMCKWNKAH-UHFFFAOYSA-N | [SMILES]
O1C(C)(C)C(C)(C)OB1 | [CAS DataBase Reference]
25015-63-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS02 | [Signal word ]
Danger | [Hazard statements ]
H225-H261 | [Precautionary statements ]
P210-P231+P232-P233-P280-P302+P335+P334-P370+P378 | [Hazard Codes ]
F,Xi | [Risk Statements ]
R11:Highly Flammable.
R15:Contact with water liberates extremely flammable gases.
R36/37/38:Irritating to eyes, respiratory system and skin .
R36/37:Irritating to eyes and respiratory system .
R19:May form explosive peroxides. | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S43:In case of fire, use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add-Never use water) .
S8:Keep container dry .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S33:Take precautionary measures against static discharges .
S29:Do not empty into drains . | [RIDADR ]
UN 3398 4.3/PG 2
| [WGK Germany ]
3
| [Hazard Note ]
Highly Flammable/Keep Cold/Air Sensitive | [REACH Registrations]
Active | [HazardClass ]
4.3 | [PackingGroup ]
II | [HS Code ]
29209090 | [Storage Class]
4.3 - Hazardous materials which set free flammable gases upon contact with water | [Hazard Classifications]
Flam. Liq. 2
Water-react 2 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Dichloromethane-->Pinacol-->Borane-methyl sulfide complex | [Preparation Products]
3-Morpholinophenylboronic acid pinacol ester-->2-Ethoxycarbonylphenylboronic acid pinacol ester-->4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline-->4-Hydroxyphenylboronic acid pinacol ester-->BISPINACOLATOBIBORATE-->1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-[(4-methylphenyl)methoxy]--->1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-(phenylmethoxy)--->4-Nitrophenylboronic acid pinacol ester-->1-Boc-pyrazole-4-boronic acid pinacol ester-->2-Amino-5-fluorophenyl boronic acid pinacol ester-->2-Amino-5-fluorobenzeneboronic acid-->3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-->(S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate-->2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane-->2-(3,4-Dihydro-2H-pyran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane-->4-(N-Methylamino)phenylboronic acid, pinacol ester |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless liquid | [Uses]
Pinacolborane is used for synthesis of unsymmetrical biaryls via aromatic C-H borylation-cross-coupling sequence.
| [Synthesis]
Pinacol (177 g, 1.5 mol) and CH2Cl2 (1.6 L) were added to a 5 L round bottom flask. Borane dimethyl sulfide (10 M, 159 mL, 0.16 mol) was added to the flask via cannula and the mixture was stirred at 0°C for 4 hours. The reaction mixture was then heated to |
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J & K SCIENTIFIC LTD.
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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