| Identification | Back Directory | [Name]
(2S,3aS,4S,5R,7R,8S,8aS,9R)-Octahydro-2,8a-dihydroxy-4,8,9-trimethyl-1-oxo-5-(2,3,5,8-tetrahydro-1,3-dioxo-2-phenyl-1H-[1,2,4]triazolo[1,2-a]pyridazin-6-yl)-1H-3a,8-propanoazulen-7-yl 2-chloroacetate | [CAS]
2505218-38-0 | [Synonyms]
Ferroptocide
(2S,3aS,4S,5R,7R,8S,8aS,9R)-Octahydro-2,8a-dihydroxy-4,8,9-trimethyl-1-oxo-5-(2,3,5,8-tetrahydro-1,3-dioxo-2-phenyl-1H-[1,2,4]triazolo[1,2-a]pyridazin-6-yl)-1H-3a,8-propanoazulen-7-yl 2-chloroacetate | [Molecular Formula]
C30H36ClN3O7 | [MOL File]
2505218-38-0.mol | [Molecular Weight]
586.08 |
| Chemical Properties | Back Directory | [Boiling point ]
695.2±65.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [solubility ]
DMSO: Soluble
Methanol: Soluble | [pka]
11.97±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Ferroptocide is a cell death inducer that triggers ferroptosis and has anti-tumor activity. Ferroptocide can induce oxidative stress, leading to G2/M cell cycle arrest and apoptosis activation in LNCaP cells, while also effectively inhibiting the cell viability of both LNCaP and TRAMP-C1 cells. Ferroptocide can be used to study its capability to induce mitochondrial autophagy and to trigger immunogenic cell death (ICD) in prostate cancer cells[1]. | [References]
[1] Hillary Shah, et al. Evaluation of Ferroptocide (FTC) As a Potential Immunogenic Cell Death Inducing Agent in Prostate Cancer Cells. Biochemistry and Molecular Biology. 2021.35.S1.03356. |
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