ChemicalBook--->CAS DataBase List--->2508-72-7

2508-72-7

2508-72-7 Structure

2508-72-7 Structure
IdentificationMore
[Name]

Antazoline hydrochloride
[CAS]

2508-72-7
[Synonyms]

2-(N-BENZYLANILINOMETHYL)-2-IMIDAZOLINE HYDROCHLORIDE
2-(N-BENZYLANILINOMETHYL) IMIDAZOLINE HYDROCHLORIDE
2-(N-PHENYL-N-BENZYL-AMINOMETHYL)-IMIDAZOLINE HCL
4,5-DIHYDRO-N-PHENYL-N-(PHENYLMETHYL)-1H-IMIDAZOLE-2-METHANAMINE HYDROCHLORIDE
ANTAZOLINE HCL
ANTAZOLINE HYDROCHLORIDE
BENZYL-(4,5-DIHYDRO-1H-IMIDAZOL-2-YLMETHYL)-PHENYL-AMINE HCL
LABOTEST-BB LT00134672
N-BENZYL-N-(2-IMIDAZOLIN-2-YLMETHYL)ANILINE HYDROCHLORIDE
2-((n-benzylanilino)methyl)-2-imidazolinhydrochloride
2-((n-benzylanilino)methyl)-2-imidazolinmonohydrochloride
2-(n-phenyl-n-benzylaminomethyl)imidazolinehydrochloride
2-phenylbenzylaminomethylimidazolinehydrochloride
antistinehydrochloride
fenazolina
histazine
Antazolin Hcl
2-(N-Benzyl-N-phenylaminonomethyl)-2-imidazoline
N-BENZYL-N-(2-IMIDAZOLIN-2-YLMETHY)ANILINE
2-Phenyl-benzyl-amino-methylimidazolin hydrochloride
[EINECS(EC#)]

219-719-8
[Molecular Formula]

C17H20ClN3
[MDL Number]

MFCD00058145
[Molecular Weight]

301.81
[MOL File]

2508-72-7.mol
Chemical PropertiesBack Directory
[Appearance]

White or almost white crystalline powder
[Melting point ]

238 °C
[storage temp. ]

Inert atmosphere,Room Temperature
[solubility ]

DMSO (Slightly, Heated), Methanol (Slightly)
[form ]

neat
[color ]

White to Off-White
[Merck ]

680
[CAS DataBase Reference]

2508-72-7(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xn,Xi
[Risk Statements ]

R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
[WGK Germany ]

3
[RTECS ]

NJ2150000
[HS Code ]

2933.29.4300
Hazard InformationBack Directory
[Chemical Properties]

White or almost white crystalline powder
[Originator]

Antistine HCl,Ciba,US,1948
[Uses]

Antazoline Hydrochloride acts as a histamine H1 receptor blocker, functioning as an antihistamine pharmaceutical.
[Uses]

Antihistaminic;H1 antagonist
[Uses]

Imidazoline binding site ligand and an antihistamine
[Manufacturing Process]

15.4 parts of 2-chloromethylimidazoline hydrochloride, 45.8 parts of Nbenzylaniline and 150 parts of alcohol are heated in an oil bath at 100° to 110°C. After distilling off the alcohol, the reaction mass is maintained at this temperature for a further 3 hours and then triturated with water and 10 parts of sodium bicarbonate. The unconsumed benzylaniline is extracted with ether and the aqueous solution neutralized with dilute hydrochloric acid. By evaporating this solution and extracting the residue with alcohol there is obtained 2-(N-phenyl-N-benzylaminomethyl)imidazoline hydrochloride in the form of colorless crystals of melting point 227° to 229°C.
[Therapeutic Function]

Antihistaminic
[Biological Activity]

Imidazoline binding site ligand; a potent inducer of insulin secretion in rat pancreas. Also an antihistamine.
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

Antazoline hydrochloride(2508-72-7)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

2508-72-7(sigmaaldrich)
[TCI AMERICA]

Antazoline Hydrochloride,>98.0%(LC)(T)(2508-72-7)
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