| Identification | Back Directory | [Name]
Cyclohexanol, 2-[(cyclohexylmethyl)amino]-1-(2-phenylethynyl)-, (1R,2S)-rel- | [CAS]
2512200-83-6 | [Synonyms]
BB 0305179
Cyclohexanol, 2-[(cyclohexylmethyl)amino]-1-(2-phenylethynyl)-, (1R,2S)-rel- | [Molecular Formula]
C21H29NO | [MOL File]
2512200-83-6.mol | [Molecular Weight]
311.46 |
| Hazard Information | Back Directory | [Uses]
BB 0305179 (compound 59) is a potent anti-prion agent, with an IC50 of 4.7 μM. BB 0305179 inhibits the toxicity of a specific PrP mutant carrying a deletion in the hydrophobic domain [1]. BB 0305179 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Altieri A, et al. Generation, optimization and characterization of novel anti-prion compounds. Bioorg Med Chem. 2020 Nov 1;28(21):115717. DOI:10.1016/j.bmc.2020.115717 |
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