| Identification | Back Directory | [Name]
Benzoic acid, 4-[1-(6-methyl-4-isoquinolinyl)-1H-1,2,3-triazol-4-yl]- | [CAS]
2512847-06-0 | [Synonyms]
LANA-DNA-IN-1
Benzoic acid, 4-[1-(6-methyl-4-isoquinolinyl)-1H-1,2,3-triazol-4-yl]- | [Molecular Formula]
C19H14N4O2 | [MOL File]
2512847-06-0.mol | [Molecular Weight]
330.34 |
| Chemical Properties | Back Directory | [Boiling point ]
632.2±65.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.66±0.10(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Uses]
LANA-DNA-IN-1 is a potent LANA-DNA inhibitor. LANA-DNA-IN-1 has inhibition activity for LBS2, LBS1 and LBS3 with IC50 values of 8 μM, 9μM and 8μM. LANA-DNA-IN-1shows against wild-type LANA with IC50 value of 53 μM. LANA-DNA-IN-1 can be used for the research of infection[1]. | [References]
[1] Philine Kirsch, et al. Hit-to-lead optimization of a latency-associated nuclear antigen inhibitor against Kaposi's sarcoma-associated herpesvirus infections. Eur J Med Chem. 2020 Sep 15;202:112525 DOI:10.1016/j.ejmech.2020.112525 |
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