| Identification | Back Directory | [Name]
Imeglimin | [CAS]
252845-37-7 | [Synonyms]
Veldoreotide
ABFNTRQPWNXUHA-UHFFFAOYSA-N
Glycinamide, N-(4-amino-1-oxobutyl)-L-phenylalanyl-L-tryptophyl-D-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-N2-(3-carboxypropyl)-, (7→1)-lactam | [Molecular Formula]
C60H74N12O10 | [MDL Number]
MFCD28964044 | [MOL File]
252845-37-7.mol | [Molecular Weight]
1123.3 |
| Hazard Information | Back Directory | [Uses]
Veldoreotide (DG3173) a somatostatin analogue, binds to and activate the somatostatin receptors (SSTR) 2, 4, and 5. Veldoreotide inhibits growth hormone (GH) secretion in adenomas compared with Octreotide (HY-P0036). Veldoreotide has the potential to be used as pain modulating agent[1] | [IC 50]
SSTR2: 37.6 nM (EC50); SSTR3: 31.3 nM (EC50); SSTR4: 10.5 nM (EC50) | [References]
[1] Dasgupta P, et al. Pharmacological Characterization of Veldoreotide as a Somatostatin Receptor 4 Agonist. Life (Basel). 2021 Oct 12;11(10):1075. DOI:10.3390/life11101075
[2] Pl?ckinger U, et al. DG3173 (somatoprim), a unique somatostatin receptor subtypes 2-, 4- and 5-selective analogue, effectively reduces GH secretion in human GH-secreting pituitary adenomas even in Octreotide non-responsive tumours. Eur J Endocrinol. 2012 Feb;166(2):223-34. DOI:10.1530/EJE-11-0737 |
|
| Company Name: |
Fuan Bio
|
| Telephone: |
15002819872 |
| Website: |
fuanbio.com |
|