| Identification | Back Directory | [Name]
2,6-Piperidinedione, 3-[4-(5-aminopentyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, 2,2,2-trifluoroacetate (1:1) | [CAS]
2550398-71-3 | [Synonyms]
Lenalidomide-C5-NH2 (TFA)
2,6-Piperidinedione, 3-[4-(5-aminopentyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, 2,2,2-trifluoroacetate (1:1) | [Molecular Formula]
C20H24F3N3O5 | [MOL File]
2550398-71-3.mol | [Molecular Weight]
443.42 |
| Hazard Information | Back Directory | [Uses]
Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader[1][2]. | [IC 50]
Cereblon | [References]
[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816
[2] Li Y, Yang J, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019;62(2):448-466. DOI:10.1021/acs.jmedchem.8b00909 |
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