| Identification | More | [Name]
4-(4-Fluorobenzoyl)piperidine hydrochloride | [CAS]
25519-78-2 | [Synonyms]
4-(4-FLUOROBENZOYL)PIPERIDINE HCL
4-(4'-FLUOROBENZOYL)PIPERIDINE HYDROCHLORIDE
4-(4-FLUOROBENZOYL)PIPERIDINE HYDROCHLORIDE
4-FLUOROPHENYL 4-PIPERIDINYL METHANONE
(4-FLUOROPHENYL)(4-PIPERIDYL)METHANONE HYDROCHLORIDE
(4-FLUORO-PHENYL)-PIPERIDIN-4-YL-METHANONE HYDROCHLORIDE
4-(P-FLUOROBENZOYL)PIPERIDINE HYDROCHLORIDE
BUTTPARK 99\50-17
p-fluorophenyl 4-piperidyl ketone hydrochloride
4-(4-Fluorobenzoyl)piperidine hydrochloride 97%
4-(4-Fluorobenzoyl)piperidinehydrochloride97%
4-(4'-Fluorobenzoyl)piperidine hydrochloride | [EINECS(EC#)]
247-070-0 | [Molecular Formula]
C12H15ClFNO | [MDL Number]
MFCD00044912 | [Molecular Weight]
243.71 | [MOL File]
25519-78-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
222-224°C | [density ]
1.31g/cm3 at 20℃ | [vapor pressure ]
0-0Pa at 20-25℃ | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly), Water (Slightly) | [form ]
Solid | [color ]
Pale Tan | [Sensitive ]
Hygroscopic | [InChI]
InChI=1S/C12H14FNO.ClH/c13-11-3-1-9(2-4-11)12(15)10-5-7-14-8-6-10;/h1-4,10,14H,5-8H2;1H | [InChIKey]
GPKDBZQZPNOBGM-UHFFFAOYSA-N | [SMILES]
C1(C=CC(F)=CC=1)C(=O)C1CCNCC1.Cl | [LogP]
-1.1 at 20℃ and pH7 | [CAS DataBase Reference]
25519-78-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,C,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S22:Do not breathe dust . | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT, MOISTURE SENSITIVE, CORROSIVE | [HS Code ]
2933399990 |
| Hazard Information | Back Directory | [Uses]
4-(4-Fluorobenzoyl)piperidine hydrochloride is a piperidnyl derivative used in the preparation of antiarrhythmics as well as α1-adrenoceptor and S2-receptor antagonists for circulatory diseases.
| [Uses]
4-(4-Fluorobenzoyl)piperidine, HCl | [Synthesis]
A solution of 70.6 of 1-acetyl-4-(4-fluorobenzoyl)piperidine in 200 ml
of 6N HCl is refluxed for 2 hours. The cooled solution is extracted
twice with ether, the aqueous solution basified with sodium hydroxide
and then extracted with benzene. The benzene extracts are dried,
filtered and the filtrate is concentrated under reduced pressure. The
residual oil is dissolved in ether and HCl gas is bubbled into the
solution with stirring. The salt is collected by filtration, washed with
ether and dried. The salt is recrystallized from isopropanol to give
the solid product of 4-(4-fluorobenzoyl)piperidine hydrochloride, mp
222°-224° C. |
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