| Identification | Back Directory | [Name]
1,2-dipalMitoyl-d62-sn-glycero-3-phosphocholine | [CAS]
25582-63-2 | [Synonyms]
KILNVBDSWZSGLL-PWXLRKPBSA-N
1,2-Dipalmitoyl-d31-sn-glycero-3-PC
1,2-DIPALMITOYL-D62-SN-GLYCERO-3-PHOSPHOCHOLINE;16:0 PC-D62
1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE (DPPC)(DIPALMITOYL-D62, 97% | [Molecular Formula]
C40H18D62NO8P | [MOL File]
25582-63-2.mol | [Molecular Weight]
796.421 |
| Hazard Information | Back Directory | [Description]
1,2-Dipalmiotyl-d31-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PC by GC- or LC-MS. 1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications. It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes. Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice. | [Uses]
DPPC-d62 is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers[1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice[2]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Miller AD. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811. DOI:10.1586/17434440.2013.855471
[3] Akiko Uemura, et al. Induction of immune responses against glycosphingolipid antigens: comparison of antibody responses in mice immunized with antigen associated with liposomes prepared from various phospholipids. J Vet Med Sci. 2005 Dec;67(12):1197-201. DOI:10.1292/jvms.67.1197 |
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| Company Name: |
Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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