| Identification | Back Directory | [Name]
5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile | [CAS]
2560576-15-8 | [Synonyms]
5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile | [Molecular Formula]
C21H13F7N4O3 | [MOL File]
2560576-15-8.mol | [Molecular Weight]
502.34 |
| Hazard Information | Back Directory | [Uses]
PYR01 is a non-nucleoside reverse transcriptase inhibitor and a killing activator targeting HIV infected cells. PYR01 has cytokilling and antiviral properties of HIV-1 infection with the IC50 values of 27.5nM and 39.7nM, respectively. PYR01 leads to selective cytotoxicity by promoting HIV-1 Gag-Pol dimerization and HIV-1 protease intracellular activation. PYR01 can be used in the study of HIV[1]. | [References]
[1] Carl J Balibar, et al. Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1. Sci Transl Med. 2023 Feb 22;15(684):eabn2038. DOI:10.1126/scitranslmed.abn2038 |
|
|