| Identification | Back Directory | [Name]
2H-1,4-Benzodiazepin-2-one, 4-[(5-bromo-2-thienyl)carbonyl]-5-(3,5-dimethylphenyl)-1,3,4,5-tetrahydro-7-methyl-, (5R)- | [CAS]
2561471-27-8 | [Synonyms]
SGC-6870 SGC 6870
2H-1,4-Benzodiazepin-2-one, 4-[(5-bromo-2-thienyl)carbonyl]-5-(3,5-dimethylphenyl)-1,3,4,5-tetrahydro-7-methyl-, (5R)- | [Molecular Formula]
C23H21BrN2O2S | [MOL File]
2561471-27-8.mol | [Molecular Weight]
469.39 |
| Chemical Properties | Back Directory | [Boiling point ]
632.8±55.0 °C(Predicted) | [density ]
1.408±0.06 g/cm3(Predicted) | [solubility ]
Soluble to 100 mM in DMSO and to 100 mM in ethanol | [pka]
13.31±0.40(Predicted) |
| Hazard Information | Back Directory | [Description]
SGC6870 is a novel potent, selective, and cell-active inhibitor of PRMT6 with IC50 of 77 ± 6 nM, being selective over all other PRMTs and 23 methyltransferases. | [Uses]
SGC6870 is a potent, selective and cytoactive allosteric inhibitor of PRMT6 with IC50 of 77 nM[1]. | [storage]
Store at -20°C | [References]
[1] Shen Y, et al. A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. J Med Chem. 2021 Apr 8;64(7):3697-3706. doi: 10.1021/acs.jmedchem.0c02160. Epub 2021 Feb 16. PMID: 33591753; PMCID: PMC8035306. DOI:10.1021/acs.jmedchem.0c02160 |
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