| Identification | Back Directory | [Name]
Benzenesulfonamide, N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[[4-(trifluoromethyl)phenyl]methyl]amino]- | [CAS]
2563892-44-2 | [Synonyms]
Benzenesulfonamide, N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[[4-(trifluoromethyl)phenyl]methyl]amino]- | [Molecular Formula]
C19H19F3N4O2S | [MOL File]
2563892-44-2.mol | [Molecular Weight]
424.44 |
| Chemical Properties | Back Directory | [Boiling point ]
613.2±65.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.76±0.50(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C19H19F3N4O2S/c1-23-29(27,28)15-7-8-17(16(9-15)18-11-26(2)12-25-18)24-10-13-3-5-14(6-4-13)19(20,21)22/h3-9,11-12,23-24H,10H2,1-2H3 | [InChIKey]
TVBGCXJDLVRDSU-UHFFFAOYSA-N | [SMILES]
C1(S(NC)(=O)=O)=CC=C(NCC2=CC=C(C(F)(F)F)C=C2)C(C2=CN(C)C=N2)=C1 |
| Hazard Information | Back Directory | [Uses]
IK-930 (compound I-32) is a potent and orally active TEAD inhibitor with an EC50 value of <0.1 μM[1]. | [in vivo]
IK-930 (compound I-32) (10 mg/kg; p.o.) shows good pharmacokinetic parameters with Cmax of 1088 ng/mL, AUC 0-last of 4581 ng*h/mL in BALB/c mice[1]. | [References]
[1] Alfredo C. Castro, et al. Tead inhibitors and uses thereof. WO2020243415A2. |
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