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2573781-75-4

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2573781-75-4 Structure

2573781-75-4 Structure
IdentificationBack Directory
[Name]

1-Propanesulfonamide, N-[2-chloro-3-[(3,4-dihydro-3,5-dimethyl-4-oxo-6-quinazolinyl)amino]-4-fluorophenyl]-3-fluoro-
[CAS]

2573781-75-4
[Synonyms]

Tinlorafenib
Tinlorafenib (compound 10)
1-Propanesulfonamide, N-[2-chloro-3-[(3,4-dihydro-3,5-dimethyl-4-oxo-6-quinazolinyl)amino]-4-fluorophenyl]-3-fluoro-
[Molecular Formula]

C19H19ClF2N4O3S
[MOL File]

2573781-75-4.mol
[Molecular Weight]

456.89
Chemical PropertiesBack Directory
[Boiling point ]

569.6±60.0 °C(Predicted)
[density ]

1.48±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 125 mg/mL (273.59 mM; Need ultrasonic)
[form ]

Solid
[pka]

7.20±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Tinlorafenib (PF-07284890) (compound 10) is an orally active BRAF kinase inhibitor, with IC50s of 4.25 and 2.7 nM for BRAFV600E/V600K respectively. Tinlorafenib demonstrates CNS penetration and can be used in the research of BRAF-associated malignant and benign tumors of the CNS as well as extracranial malignancies[1].
[IC 50]

BRafV600E: 4.25 nM (IC50); BRafV600K: 2.7 nM (IC50)
[References]

[1] Barbour, et al. Quinazolin-4-one derivatives useful for the treatment of braf-associated diseases and disorders. WO2020261156A1.
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