| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2582757-90-0 | [Synonyms]
Stafia1,domain,Inhibitor,STAT,selectivity,leukemia,inhibit,cells,Stafia 1,Stafia-1,SH2 | [Molecular Formula]
C24H27O10P | [MDL Number]
MFCD32899895 | [MOL File]
2582757-90-0.mol | [Molecular Weight]
506.44 |
| Chemical Properties | Back Directory | [Boiling point ]
649.0±65.0 °C(Predicted) | [density ]
1.296±0.06 g/cm3(Predicted) | [solubility ]
DMSO: Slightly Soluble: 0.1-1 mg/ml
Ethanol: Sparingly Soluble: 1-10 mg/ml | [form ]
Solid | [pka]
1.11±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Stafia-1 is a potent STAT5a inhibitor (K i=10.9 μM, IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members[1]. | [IC 50]
STAT5a: 10.9 μM (Ki); STAT5a: 22.2 μM (IC50) | [References]
[1] Natarajan K, et al. Stafia-1: a STAT5a-Selective Inhibitor Developed via Docking-Based Screening of in Silico O-Phosphorylated Fragments. Chemistry. 2020;26(1):148-154. DOI:10.1002/chem.201904147 |
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